How Gut Bacteria Let Us Know When To Stop Eating

In a healthy gut, microbes wax and wane throughout the day

Salk researchers find that metabolic disease and obesity may be caused, in part, by abnormal behavior of certain gut bacteria

LA JOLLA–Taking a single snapshot of all the bacteria that live in a mouse’s–or person’s–stomach and intestines can capture the health of the organism’s digestive system and even their risk of developing immune diseases and cancers. But it might take more than one snapshot to get a full picture, Salk researchers have discovered.

In the journal Cell Metabolism published December 2, 2014, the scientists at the Salk Institute compared the microbiomes of mice fed normal food versus those given high-fat chow.  Rather than take one daily measurement of the animals’ gut microbes, they measured the populations of microbes every four hours. In the mice on normal diets–who eat during the night and sleep during the day–the researchers saw dramatic fluctuations in the particular genera of bacteria present at any given time. But in the mice that were on a high-fat diet–and generally eat around the clock, gain weight and develop diabetes–the microbes remained more constant. (read from the Salk Institute news).

  • The article can be accessed at http://www.cell.com/cell-metabolism/abstract/S1550-4131(14)00505-1

To Fix Your Brain, Fix Your Gut!

Last Updated: 2015-12-01

Our Gut Bacteria May Be the Cause for Metabolic Disease and Obesity